CTRI/2021/11/038340尚未招募未知
Bridging therapy with intravenous Alteplase in imaging eligible Acute Ischemic Stroke patients with onset between 4.5 to 9 hours - A Randomized Controlled, Pilot Study
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Age > 18 years
- •-Acute Ischemic Stroke symptom onset within past 4.5-9 hours
- •-Acute Ischemic Stroke consistent within ICA, MCA or ACA territory
- •-Baseline mRS 0-2
- •-NIHSS score of >5 at baseline and prior to
- •randomization
- •-Imaging eligibility with perfusion lesion ischemic core mismatch greater than 1.8 between
- •the volume of hypoperfusion and volume of the
- •ischemic core, an absolute difference in volume
- •greater than 10 ml, and an ischemic-core volume
- •of less than 70 ml
排除标准
- •-Imaging shows more than 1/3 of MCA territory
- •infarct or more than one vascular territory
- •-Acute or previous intracranial hemorrhage
- •-Active internal organ bleeding
- •- Known hypersensitivity to Alteplase
- •- Seizures at stroke onset
- •-Severe, uncontrolled hypertension
- •- Treatment with a thrombolytic within last 3
- •-Prior ischemic stroke, severe head trauma,
- •intracranial/intraspinal injury within 3 months
- •-Gastrointestinal malignancy or GI bleed within
- •-Occlusion in > 1 vascular territory
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