The Effects of Splenda (Sucralose) on Blood Glucose Concentration, Appetite Scores and Subsequent Energy Intake in Humans: a Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Change in blood glucose
研究概览
简要总结
This study investigates the effects of Splenda, an artificial sweetener powder containing sucralose, on post-prandial blood glucose levels, appetite scores and subsequent energy intake.
详细描述
Participants are randomly assigned to receive either the placebo drink (4.5g maltodextrin dissolved in 250ml water) or the Splenda drink (4.5g Splenda dissolved in 250ml water) taken alongside a high calorie breakfast.
Blood glucose measurements will be obtained through finger-pricking and appetite will be measured using self-reported visual analogue scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast. Energy intake will be measured using a 24 hour food diary.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male and female adults (18-64 years)
排除标准
- 未提供
研究组 & 干预措施
Splenda drink
Drink containing 4.5g Splenda dissolved on 250ml water.
干预措施: High carbohydrate breakfast (Dietary Supplement)
Maltodextrin drink
Drink containing 4.5g maltodextrin dissolved on 250ml water.
干预措施: Maltodextrin drink (Dietary Supplement)
Maltodextrin drink
Drink containing 4.5g maltodextrin dissolved on 250ml water.
干预措施: High carbohydrate breakfast (Dietary Supplement)
Splenda drink
Drink containing 4.5g Splenda dissolved on 250ml water.
干预措施: Splenda drink (Dietary Supplement)
结局指标
主要结局
Change in blood glucose
时间窗: -5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)
Capillary blood glucose from fingerprick and measured using glucose monitor
Change in appetite
时间窗: -5 to 180 minutes (measured from baseline up to 90min every 15min and from 90-180min every 30min)
Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analogue Scale (VAS)
次要结局
- 24 hour energy intake(0 - 24 hours)
研究者
Dr Christopher Corpe
Nutrition Sciences Lecturer, Principal investigator
King's College London