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临床试验/NCT04211038
NCT04211038Unknown不适用

Assessment of Neural Inspiratory Time Through Transesophageal and Surface Electromyography

Zhenfeng He1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2019年12月27日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
30
试验地点
1
主要终点
the onset and duration of neural inspiratory time

研究概览

简要总结

The onset and offset of the neural inspiratory time are fundamentally important measurements in studies of patientventilator interaction, where the level of assistance delivered by the ventilator is controlled by the patient's demand. The onset of neural inspiratory time can be determined in esophageal pressure, transdiaphragmatic pressure, and EMG signals. The investigator compare the onset measured by EMG, esophageal and transdiaphragmatic pressure, and consider that the correlation between them is well in different conditions.

详细描述

The onset and offset of the neural inspiratory time are fundamentally important measurements in studies of patien-tventilator interaction, where the level of assistance delivered by the ventilator is controlled by the patient's demand. Patient-ventilator asynchrony evaluated using the time lag between onset of the neural inspiratory time and the onset of a mechanical ventilation signal. The onset of neural inspiratory time can be determined in esophageal pressure, transdiaphragmatic pressure, and EMG signals. The investigator compare the onset measured by EMG, esophageal and transdiaphragmatic pressure, and consider that the correlation between them is well in three different conditions.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Other
盲法
None

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • normal cardio-pulmonary function
  • without low inspiratory muscle strength
  • non-smoker
  • without history of the nervous system and respiratory system disease
  • sever to very severe stable stage

排除标准

  • systemic application of corticosteroids nearly 4 weeks

结局指标

主要结局

the onset and duration of neural inspiratory time

时间窗: through study completion, an average of 5 hours

Correlation between onsets and duration of measured from espphageal pressure, transdiaphragmatie pressure and EMG.

次要结局

未报告次要终点

研究者

发起方
Zhenfeng He
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Zhenfeng He

principal investigator

Guangzhou Medical University

研究点 (1)

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