NCT00002433已完成不适用
Activation of Alveolar Macrophages by Aerosolized r-metHuIFN-Gamma (IFN-Gamma) in Patients With AIDS
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Amgen
- 入组人数
- 12
- 试验地点
- 1
研究概览
简要总结
To determine safety and tolerance of administering aerosolized recombinant interferon gamma (IFN-gamma) for 4 weeks in patients with AIDS. To examine activation of alveolar macrophages by aerosolized IFN-gamma administration. To determine if subcutaneous (SC) injection of IFN-gamma can activate alveolar macrophages in AIDS patients.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have:
- •Diagnosis of AIDS with one or more opportunistic infections.
- •Kaposi's sarcoma with prior history of opportunistic infection.
- •Stable dose of zidovudine (AZT) therapy.
- •Preserved pulmonary, renal and hepatic function.
排除标准
- •Co-existing Condition:
- •Patients with the following conditions or symptoms are excluded:
- •Presence of active infection.
- •Active opportunistic infections.
- •Cardiac disease.
- •Central nervous system disorders.
- •History of seizures.
- •Irreversible airway disease.
- •Patients with the following are excluded:
- •Co-existing conditions and symptoms listed in Patient Exclusion Co-existing Conditions.
- •Prior Medication:
- •Excluded within 4 weeks of study entry:
- •Immunosuppressive therapy.
- •Cytotoxic therapy.
- •Excluded:
- •Interferon gamma therapy.
研究者
研究点 (1)
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