Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- Digital count of e.faecalis
研究概览
简要总结
Evaluation of the Effect of Grape Seed Extract, Glycyrrhizin Compared to Triple Antibiotic Paste as Intra Canal Medication in Revascularization of Necrotic Permanent Immature Teeth in Children: A Randomized Clinical Trial
详细描述
Digital count of e.faecalis before and after application of different type of intra canal medication
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 13 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy children aged from 7-13 years old.
- •Patient with necrotic pulp.
- •Open apex.
排除标准
- •Teeth with root fractures.
- •Presence of root resorptions.
- •Presence of periodontal pockets.
- •Developmental anomalies.
- •Tooth with class III mobility
研究组 & 干预措施
Group a
Revascularization with triple antibiotic paste as intracanal medication
干预措施: Triple Antibiotic Paste (Drug)
Group b
Revascularization with grape seed extract as intra canal medication
干预措施: Grape Seed Extract (Drug)
Group c
Revascularization with glycyrrhizin as intracanal medication
干预措施: Glycyrrhizin (Drug)
结局指标
主要结局
Digital count of e.faecalis
时间窗: After One week of mediation application
Microbiological evaluation The number of E. faecalis will be digitally counted.
Clinical evaluation success will be assessed using following criteria of success according to scoring system Absence of : - Pain, - Soft tissue swelling - soft tissue inflammation - Sinus tract - tenderness to percussion - tooth mobility
时间窗: After one week of mediation application
Clincal success will be assessed using following criteria of success according to clinical scoring system Absence of : * Pain, * Soft tissue swelling * soft tissue inflammation * Sinus tract * tenderness to percussion * tooth mobility. Clinical score Clinical symptom Definition 1. asymptomatic Pathology: absent Normal functioning Mobility (physiological) ≤1mm 2. Slight discomfort, short-lived Pathology: questionable Percussion sensitivity Gingival inflammation (due to poor oral hygiene) Mobility (physiological) \> 1mm, but \<2mm 3. Minor discomfort, short-lived Pathology: initial changes present Gingival swelling (not due to poor oral hygiene) Mobility \> 2mm, but \< 3 mm 4. Major discomfort, long-lived extract immediately Pathology: late changes present Spontaneous pain Gingival swelling (not due to poor oral hygiene) Periodontal pocket formation(exudate) Sinus tract present Mobility ≥ 3mm Premature tooth loss, due to pathology
次要结局
- Radiographic evaluation(After tweleve month)
研究者
Mohamed Khalifa
Doctor of dental medicine
Al-Azhar University