The Effect of Sevoflurane Versus Isoflurane on Vasopressor Need
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 发起方
- UMC Utrecht
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Total amount of the vasopressor phenylephrine that is needed to maintain blood pressure above 60 mmHg during 10 minutes of Cardiopulmonary bypass.
研究概览
简要总结
Aim of this study is to determine the effect of isoflurane versus sevoflurane on blood pressure and systemic vascular resistance.
详细描述
In modern anesthesia a variety of volatile anesthetics is available. In cardiac anesthesiology both isoflurane and sevoflurane are frequently used. At present the number of studies comparing the influence of isoflurane and sevoflurane on blood pressure and systemic vascular resistance is limited. Moreover, the results presented in the available literature are inconsistent. The decision as to which of both volatiles should be used during cardiac surgery is not evidence-based, but is based on personal preference of the anesthesist. The most reliable way to compare the effects of isoflurane and sevoflurane on blood pressure and systemic vascular resistance is a randomized controlled trial in patients during Cardiopulmonary bypass (CPB).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •competent adult patients (18 years or older)undergoing elective coronary artery bypass grafting with the use of the cardiopulmonary bypass.
排除标准
- •Patients undergoing valve surgery or combined surgical procedures (e.g. coronary artery bypass grafting in combination with valve reconstruction.
- •uncontrolled hypertension
- •a poor left ventricular function
- •renal failure
- •a body mass index of > 25
- •history of cerebrovascular accident, transient ischemic accident or carotid artery stenosis.
研究组 & 干预措施
Sevoflurane
Administration of the volatile anesthetic Sevoflurane.
干预措施: Sevoflurane and isoflurane (Drug)
Isoflurane
Administration of the volatile anesthetic Isoflurane.
干预措施: Sevoflurane and isoflurane (Drug)
结局指标
主要结局
Total amount of the vasopressor phenylephrine that is needed to maintain blood pressure above 60 mmHg during 10 minutes of Cardiopulmonary bypass.
时间窗: 10 minutes
次要结局
- Mean blood pressure throughout the 10 minute periods, the need for a stronger vasopressor (norepinephrine) and the inability to keep mean blood pressure below 75 mmHg at MAC 0.6.(10 minutes)