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临床试验/NCT03935230
NCT03935230已完成不适用

Uncontrolled Donation After Circulatory Determination of Death (uDCDD): A Potential Solution to the Shortage of Organs in Quebec?

Université de Sherbrooke0 个研究点目标入组 1,111 人开始时间: 2016年5月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
1,111
主要终点
Potential contribution of a uDCDD program on the number of additional donors.

研究概览

简要总结

World-wide, patients waiting for organ transplantation exceed the number of organs available. Many European countries have a uDCDD program which contribute to 10-15% of the donor pool. In Canada, this type of program does not exist. The purpose of this study is to report how many deceased person fulfill the criteria for uncontrolled DCDD in a Canadian medical center.

详细描述

While transplantation has become the definitive treatment for many people suffering end-stage organ failure, demand exceeds supply. For many years, donation after neurological death represented the principal source of organs for transplantation. In the last decade, prevention measures, improvements in neurocritical care, and decompressive craniectomy have led to a significant decrease in the number of non-directed donors (NDDs). In such situations, alternative sources for organ donation must be identified. Cardiac-arrest patients could provide a solution to this organ shortage. Patients who have experienced unexpected in or out of hospital cardiopulmonary arrest could become organ donors. Organ donation following uncontrolled cardiocirculatory death is currently practiced in many European countries. However, in Canada, it's not yet authorized. Yet, each deceased could save up to four lives. The purpose of this study is to determine the organ potential for a cohort of patient who had died from a cardiopulmonary arrest at the CHUS in 2015 and assess the effect of the implementation of a uDCD program on the number of additional donors.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All patients treated for cardiocirculatory arrest at the CIUSSS-Estrie CHUS in 2015.

排除标准

  • Patients with a status of no resuscitation
  • Pediatric patients (<18 years old)
  • Adults >65 years old

结局指标

主要结局

Potential contribution of a uDCDD program on the number of additional donors.

时间窗: 1 year

Defined as (must meet all criteria): * Age ≤70 years old * Absence of obvious cause of death (rigor mortis, decapitation, overwhelming traumatic injury) * Absence of surgical cause of cardiac arrest * No sign of IV drug abuse * No history of malignancies

次要结局

  • Areas of future research.(1 year)
  • Number of tissus donors(1 year)
  • Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.(1 year)
  • Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.(1 year)

研究者

申办方类型
Other
责任方
Sponsor

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