The Comparison of Effect of Four Different Treatment Protocols: Antagonist/Letrozole Protocol, Microdose Flare-up Protocol, Antagonist/Clomiphene Protocol, Antagonist on IVF Outcomes in Poor Responders Undergoing in Vitro Fertilization; a Prospective Randomized-controlled Study.
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 100
- 主要终点
- clinical pregnancy rates
研究概览
简要总结
The comparison of effect of four different treatment protocols: Antagonist/letrozole protocol, microdose flare-up protocol, Antagonist/clomiphene protocol, Antagonist on IVF outcomes in poor responders undergoing in vitro fertilization; a prospective randomized-controlled study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Criteria for definition of poor responders included at least one of the following
- •Anti müllerian hormone <1.1 ng/ml and/or a previous poor ovarian response (≤3 oocytes with a conventional stimulation protocol).
- •Primary infertile patients
- •BMI≤30 kg/m2 were included this study.
排除标准
- 未提供
研究组 & 干预措施
IVF patients
patients that has applied to Yeditepe University Hospital assisted reproduction center
干预措施: GnrH Antagonist/letrozole protocol (Cetrotide; serono + Femara; Novartis Pharma AG) (Drug)
IVF patients
patients that has applied to Yeditepe University Hospital assisted reproduction center
干预措施: microdose flare-up protocol (Lucrin; Abbott + Gonal F, Serono) (Drug)
IVF patients
patients that has applied to Yeditepe University Hospital assisted reproduction center
干预措施: Antagonist/clomiphene protocol (Cetrotide; serono + Klomen, Kocak pharma) (Drug)
IVF patients
patients that has applied to Yeditepe University Hospital assisted reproduction center
干预措施: GnRH antagonist protocol (Cetrotide, Serono) (Drug)
结局指标
主要结局
clinical pregnancy rates
时间窗: 6 months
次要结局
- total number of oocytes retrieved(6 months)
研究者
Pınar Özcan Cenksoy
Medical Doctor
Yeditepe University Hospital