Changes in Serum Fibroblast Growth Factor 21 (FGF21) Levels After a Cardiorespiratory Exercise Program
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 82
- 试验地点
- 2
- 主要终点
- Change From Baseline Fibroblast Growth Factor 21 (FGF21) Acutely and at Two Weeks
研究概览
简要总结
We evaluated the effect of two weeks of intensive supervised physical activity in serum fibroblast growth factor 21 (FGF21) levels.
详细描述
Comparative and longitudinal study. Anthropometric and biochemical evaluation were done before, 1hr and 4hr after a bout of exercise and repeated after two weeks of daily supervised exercise. We studied sedentary young healthy women. A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks. The Department of Endocrinology and Metabolism at the INCMNSZ performed all biochemical laboratory measurements using standardized procedures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Aged 18 to 35 years old,
- •Body mass index (BMI) <30 kg/m2
- •Without contraindication for exercising
排除标准
- •Metabolic syndrome
- •Dyslipidemia
- •Hypertension
- •Thyroid disease
- •Treated with fibrates, beta agonists or blockers
- •History or current arrhythmias, murmurs, cardiomegaly, or treatment for cardiovascular diseases -
- •Contraindications for exercise testing were also considered as exclusion criteria (see references)
结局指标
主要结局
Change From Baseline Fibroblast Growth Factor 21 (FGF21) Acutely and at Two Weeks
时间窗: Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise
Serum measurement of FGF21 using human ELISA kit was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise.
次要结局
- Change From Baseline Free Fatty Acids (FFAs) Acutely and at Two Weeks(Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise)
- Change From Baseline Epinephrine Acutely and at Two Weeks(Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise)
- Change From Baseline Leptin Acutely and at Two Weeks(Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise)
- Change From Baseline Total Adiponectin Acutely and at Two Weeks(Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise)
- Change From Baseline Fasting Glucose Acutely and at Two Weeks(Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise)
研究者
Daniel Cuevas-Ramos
Principal Investigator
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran