Identification and Regulation of Brown Adipose Tissue (BAT) in Humans. Implications for Energy Expenditure in Humans and in the Treatment of Obesity and Related Metabolic Diseases
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- FDG-PET/CT-scanning
研究概览
简要总结
The investigators wish to evaluate the effect of thyroid hormones on brown adipose tissue in humans in an observational study on patients with thyrotoxicosis. In the investigators evaluation the investigators will use FDG-PET/CT, indirect calorimetry and fat biopsies in the acute phase of the disease and in the euthyroid phase after treatment.
It is the investigators hypothesis that high levels of circulating T3 might affect amount and function of brown adipose tissue.
详细描述
10 patients with thyreotoxicosis (T3 > 3 nmol/L and suppressed TSH) will be investigated at diagnosis and after 3-6 months of euthyroidism induced by antithyroid treatment. The patients will all be over the age of 50 due to the radiation given by the scans (requested by the local Ethical Committee). All will be scanned for active BAT by the integrated FDG PET-CT before and after treatment.BAT is activated by means of crushed ice placed under the feet in individualized intervals during the scan procedure. Indirect calorimetry is done to determine the basal metabolic rate and subcutaneous fat biopsy to examine the effect on subcutaneous white fat and the possible "browning" effect.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •men and women with hyperthyroidism (T3 > 3 nmol/l)
- •> 50 years old
- •women must be postmenopausal
排除标准
- •thyrotoxic crises
- •severe concurrent sickness that will make it unsafe to postpone treatment, this includes severe kidney disease (creatinin over 160)- and heart disease (NYHA group 3 and 4).
- •former and current treatment with interleukin-2
- •Patients who are already treated with β-blockers
- •severe claustrophobia
- •BMI > 30 kg/m2
结局指标
主要结局
FDG-PET/CT-scanning
时间窗: 6 months
Changes in Brown adipose tissue FDG uptake
次要结局
- Indirect Calorimetry(6 months)
研究者
Peter Breining
MD
Aarhus University Hospital