Mecanical Properties of Biomaterials and Biological Integration of Diaphragmatic Prothesis in Infancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- cell colonization
研究概览
简要总结
In case of CDH, the incomplete development of a part of the diaphragm allows abdominal viscera to herniate into thorax cavity during fetal development and impaired lung and heart development.
After birth, CDH patients who survived thanks to an active reanimation management undergo diaphragmatic repair. In case of large defect, a patch is needed to complete diaphragmatic closure. Thanks to primary cell culture from foreskin, peritoneal epithelium or cremaster dedicated to incineration investigators want to analyse biological integration of actually used prothesis and others innovations.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 0 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Minor aged 0 (day of birth) to 14 years
- •Patient for whom an indication of posthectomy and / or cure of inguinal hernia and / or testicular ectopy is retained
- •Patient whose legal representatives have agreed to the use of operational waste from mesenchymal tissues (foreskin, cremaster and peritoneum) destined for incineration.
- •Patient affiliated to a social security scheme
排除标准
- •parents don't agree to the use of its operating waste for research purposes
结局指标
主要结局
cell colonization
时间窗: samples are processed immediately after sampling
Study cell colonization
quality of the extracellular matrix
时间窗: samples are processed immediately after sampling
Quality of the extracellular matrix produced in vitro in contact with the currently used implant materials compared to biomaterials under development
次要结局
未报告次要终点