Cytokine Removal by CRRT in Pediatric Sepsis: A Comparison of Convection Versus Diffusion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 10
- 主要终点
- A 25% additional decrease in IL-6 concentration change
研究概览
简要总结
This pilot study will compare the effect of diffusive versus convective Continuous Renal Replacement Therapy (CRRT) in children with sepsis who require CRRT.
The hypothesis for the study is that convective forms of CRRT provide enhanced clearance of cytokines and improved clinical responses as compared to a diffusive CRRT modality.
详细描述
The purpose of this study is to test the hypothesis that convective forms of Continuous Renal Replacement Therapy (CRRT) provides enhanced clearance of cytokines compared to a diffusive CRRT modality. Also, we plan to test the hypothesis that patients who receive convective CRRT modalities demonstrate improved clinical responses to patients who receive a diffusive CRRT modality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 1 Year 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with documented sepsis or suspected SIRS
- •Patients initiating CRRT
- •Age 1 to 21 years
排除标准
- •Patients on ECMO
- •Patients receiving concomitant plasma exchange
- •Cardiopulmonary bypass procedure within 96 hours of CRRT
- •Patients with new onset acute leukemia
- •Patients with active autoimmune disease
- •Ungrafted stem cell transplant recipients
结局指标
主要结局
A 25% additional decrease in IL-6 concentration change
时间窗: The First 24 hours of CRRT
次要结局
- Other cytokine removal rates(First 24 hours of CRRT)
- Cytokine absorption on the CRRT membrane(First 24 hours of CRRT)
- Hemodynamic parameters(First 24 hours of CRRT)
- Changes in serum cytokine concentrations and clearance(After crossover, from 24-48 hours)
- Changes in serum cytokine concentrations(From beginning to end of the study, independent of modality)