NCT04377724已完成不适用
Longitudinal Serological Study on the Spread and Course of COVID-19 Infections
Goldhahn Jörg1 个研究点 分布在 1 个国家目标入组 2,910 人开始时间: 2020年4月27日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 2,910
- 试验地点
- 1
- 主要终点
- seroprevalence as well as the titer of serum antibodies (IgM, IgG and IgA) targeting SARS-CoV-2 antigens
研究概览
简要总结
The overall goal is to study the immune response to SARS-CoV-2 infection over the period of one year in the blood of a representative cohort of ETH students/employees.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ETH employee or ETH student and their family members living in the same household at the start of the study
- •Between 18 and 64 years of age at the start of the study
- •Signed informed consent
排除标准
- •Age over 64 years at the start of the study
- •In quarantine or self-confinement at the start of the study
- •Active COVID-19 infection at the start of the study:
- •Diagnosed with a laboratory test
- •Suspected based on typical symptoms such as fever (>38°C), acute pulmonary ex-acerbation or sudden loss of gustatory taste
- •The following medical condition
- •With continuous steroid therapy/ chemotherapy/immunsuppressive therapy
- •In treatment for cancer
- •With severe autoimmune disease
结局指标
主要结局
seroprevalence as well as the titer of serum antibodies (IgM, IgG and IgA) targeting SARS-CoV-2 antigens
时间窗: 12 months
次要结局
- the property of peripheral blood mononuclear cells before and after an infection with SARS-CoV-2 as opposed to other pathogens(12 months)
- the immune response to common-cold (corona)virus and influenza virus infections in patients with COVID-19 infections(12 months)
- the property of IgM and IgA antibody titers against the nucleocapsid protein of SARS-CoV-2 in symptomatic as well as asymptomatic COVID-19 infections over the course of time following an infection(12 months)
研究者
Goldhahn Jörg
Deputy director of the Institute for Translational Medicine
ETH Zurich
研究点 (1)
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