NCT03903341已完成不适用
The Role of the Upper Colliculus in the Idiopathic Blepharospasm : a Pilot Study in Functional MRI
University Hospital, Grenoble2 个研究点 分布在 1 个国家目标入组 13 人开始时间: 2019年11月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- Visual pathways fMRI
研究概览
简要总结
This pilot study aims at investigating the role of superior colliculus in patients with idiopathic blepharospasm (BSP) de novo, compared to healthy subjects.
详细描述
The objective of the study is to investigate the function of the superior colliculus (SC) related to visual stimulation by means of fMRI (functional magnetic resonance imaging) in patients with idiopathic BSP compared to healthy subjects. The hypothesis is that SC function is impaired in BSP (role of biomarker of SC).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non treated idiopathic blepharospasm
- •Age: 30- 70 years
排除标准
- •Under the following treatments: Botulin toxin, anticholinergic, benzodiazepines, baclofen, beta- and alpha-blockers collyrium
- •No MRI Contraindication
结局指标
主要结局
Visual pathways fMRI
时间窗: In a five months period after inclusion
To measure the bold signal in superior colliculus and lateral geniculate corpus
次要结局
未报告次要终点
研究者
研究点 (2)
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