Delineation of Target Volume of Stereotactic Radiotherapy for Spinal Tumors
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Disease Control Rate（DCR）
研究概览
简要总结
The purpose of this study was to compare efficacy and side effects of two target delineation methods for stereotactic radiotherapy of metastatic spinal tumors.
详细描述
The purpose of this study was to compare efficacy and side effects of two target delineation methods for stereotactic radiotherapy of metastatic spinal tumors. This is a bidirectional cohort study planned to enroll approximately 500 patients with metastatic spinal tumors. Patients are divided into two groups according to the target delineation method. Group 1：The target bolume only includes local tumor. Group 2：The target bolume includes local tumor and adjacent vertebral area.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with spinal metastases or primary tumors receiving stereotactic radiotherapy;
- •Patients with sufficent pre-treatment imaging data
- •Patients who can cooperate with imaging review and follow-up after radiotherapy.
排除标准
- •Patients with an expected survival of less than 3 months;
- •Patients with second-course radiotherapy;
- •Patients with physical conditions that cannot tolerate stereotactic radiotherapy;
- •Patients with extensive spinal metastasis and no local therapeutic value
结局指标
主要结局
Disease Control Rate（DCR）
时间窗: 2 years
Disease Control Rate（DCR），including complete response（CR），partial response(PR) and stable disease(SD ).
Pain relief rate
时间窗: 3 months
VAS Score(Visual Analog Scale Score) decreased after treatment
次要结局
- Incidence of side effects(2 years)