Stress and Anxiety Effects on Valuation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Subjective Value Assigned to Food Stimuli
研究概览
简要总结
The purpose of this study is to understand how stress, anxiety, and negative affect change learning and decision-making processes. The primary objective is to assess two forms of decision-making-reward adaptation and emotion prediction errors-differ as a function of stress and anxiety. The secondary objectives are to assess how individual differences measured in our studies relate to these decision variables.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aims 1-3: To be eligible for participation in this study, an individual must meet all of the following criteria:
- •18-65 years of age
- •Able to speak, read, and write fluently in English
- •Be willing and able to follow study procedures and provide informed consent.
- •Aim 4: To be eligible for participation in this study, an individual must meet all of the following criteria:
- •18-65 years of age
- •Diagnosis of GAD
- •Able to speak, read, and write fluently in English
- •Be willing and able to follow study procedures and provide informed consent.
排除标准
- •Aims 1-3: Individuals will be excluded from participation if any of the following criteria are met:
- •History of or medication for neurologic or psychiatric disease
- •High-blood pressure or heart condition
- •Diabetes, food allergies, metabolic disorders or history of eating disorder
- •Use of corticosteroids or beta-blockers
- •Pregnancy
- •Aim 4: Individuals will be excluded from participation if any of the following criteria are met:
- •High-blood pressure or heart condition
- •Diabetes, food allergies, metabolic disorders or history of eating disorder
- •Use of corticosteroids or beta-blockers
- •Lifetime history of bipolar disorder or any psychotic disorder; substance use disorder in past 3 months; eating disorder in past 6 months; current major depressive disorder (past is allowed)
- •Active suicidal ideation with plan and intent (indicated by score >=4 on the Columbia Suicide Severity Scale)
- •Not on stable dose of psychiatric medication for at least 4 weeks prior to study participation
- •Pregnancy
研究组 & 干预措施
Aim 1: Socially Evaluated Cold Pressor Task (SECPT)
Participants will be randomly assigned to complete the Socially Evaluated Cold Pressor Task (SECPT). Cortisol samples will be collected throughout the study session. All participants will then complete a Food Value Task, during which they will view a series of reward stimuli (snack foods) over alternating task blocks.
干预措施: Socially Evaluated Cold Pressor Task (SECPT) (Behavioral)
Aim 1: Non-Stressful Control Task
Participants will be randomly assigned to complete a non-stressful control task. Cortisol samples will be collected throughout the study session. All participants will then complete a Food Value Task, during which they will view a series of reward stimuli (snack foods) over alternating task blocks.
干预措施: Non-Stressful Control Task (Behavioral)
Aim 2: Socially Evaluated Cold Pressor Task (SECPT)
Participants will be randomly assigned to complete the SECPT. Cortisol samples will be collected throughout the study session. Participants will then complete the Image Value Task, during which they will view a series of positive, negative or neutral images over alternating task blocks.
干预措施: Socially Evaluated Cold Pressor Task (SECPT) (Behavioral)
Aim 2: Non-Stressful Control Task
Participants will be randomly assigned to complete a non-stressful control task. Cortisol samples will be collected throughout the study session. Participants will then complete the Image Value Task, during which they will view a series of positive, negative or neutral images over alternating task blocks.
干预措施: Non-Stressful Control Task (Behavioral)
Aim 3: Socially Evaluated Cold Pressor Task (SECPT)
Participants will first complete demographic and self-report measures, followed by random assignment to complete the SECPT. Cortisol samples will be collected throughout the study session to measure neuroendocrine response to the stress/control task. Participants will then complete the Affective Prediction Error Task.
干预措施: Socially Evaluated Cold Pressor Task (SECPT) (Behavioral)
Aim 3: Non-Stressful Control Task
Participants will be randomly assigned to complete a non-stressful control task. Cortisol samples will be collected throughout the study session. Participants will then complete the Affective Prediction Task.
干预措施: Non-Stressful Control Task (Behavioral)
Aim 4: Behavioral Task
Participants with a diagnosis of generalized anxiety disorder (GAD) will complete a two-session behavioral task examining how clinical anxiety affects value and affective predictions.
结局指标
主要结局
Subjective Value Assigned to Food Stimuli
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Measured as participants' willingness-to-pay ($) for snack foods across the behavioral task. (Aims 1 and 4).
Valence Rating Score of OASIS Images
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Valence is rated on a scale from 0 (very negative) to 6 (very positive). (Aims 2 and 4)
Pleasantness Rating Score of OASIS Images
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Pleasantness is rated on a scale from 0 (very unpleasant) to 6 (very pleasant). (Aims 2 and 4)
Intensity Rating Score of OASIS Images
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Intensity is rated on a scale from 0 (very low) to 6 (very high). (Aims 2 and 4)
Subjective Value Assigned to Food Stimuli
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Measured as participants' willingness-to-pay ($) for snack foods across the behavioral task. (Aims 1 and 4).
Valence Rating Score of OASIS Images
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Valence is rated on a scale from 0 (very negative) to 6 (very positive). (Aims 2 and 4)
Pleasantness Rating Score of OASIS Images
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Pleasantness is rated on a scale from 0 (very unpleasant) to 6 (very pleasant). (Aims 2 and 4)
Intensity Rating Score of OASIS Images
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Intensity is rated on a scale from 0 (very low) to 6 (very high). (Aims 2 and 4)
Emotion Predictions - Valence
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Difference in valence ratings before and after trial outcomes. (Aims 3 and 4)
Emotion Predictions - Pleasantness
时间窗: Study Visit (Day 1 - Approx. 2 Hours)
Difference in pleasantness ratings before and after trial outcomes. (Aims 3 and 4)
次要结局
- Perceived Stress Scale (PSS) Score(Study Visit (Day 1 - Approx. 2 Hours))
- Holmes-RaHe Life Stress Inventory Score(Study Visit (Day 1 - Approx. 2 Hours))
- Multidimensional Assessment of Interoceptive Awareness (MAIA-2) Score(Study Visit (Day 1 - Approx. 2 Hours))