FLuid Responsiveness Prediction Using EXtra Systoles
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- fluid challenge response in stroke volume
研究概览
简要总结
In this study, the investigators propose to investigate a novel technique for fluid responsiveness prediction. It is based on the occurrence of an extra systole, which induces a preload variation: Extra systoles are comprised by, first, the premature/ectopic beat with decreased cardiac preload, then, the post-ectopic beat with moderately increased preload.
Consequently, the post ectopic beat is associated with a Frank-Starling curve right shift but is otherwise a normal sinus beat. As such, the post-ectopic beat elucidates and predicts the hemodynamic effect of increasing preload, i.e. giving fluids
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients requiring elective CABG or OPCAB surgery
- •Patient's age ≥ 18 years
排除标准
- •Patient refusal
- •Pregnancy
- •EF < 35%
- •End stage kidney failure (defined by the need for haemodialysis)
- •Patients with atrial fibrillation or frequent and coupled extra systoles (e.g. trigemini)
研究组 & 干预措施
fluid challenge
干预措施: fluid challenge (Other)
结局指标
主要结局
fluid challenge response in stroke volume
时间窗: during operation
To investigate if post-ectopic induced changes in blood pressure before a fluid bolus (5 ml/kg) predicts the fluid induced change in cardiac stroke volume
次要结局
未报告次要终点
研究者
Prof.dr.T.W.L.Scheeren
prof.dr.
University Medical Center Groningen