Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis.
研究概览
简要总结
Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS.
The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion.
The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with internuclear ophthalmoplegia listed as a primary or associated diagnosis
- •Patients hospitalized in a neurology department
排除标准
- •- Patients under 18 years of age
研究组 & 干预措施
Internuclear ophthalmoplegia
This is a retrospective cohort study involving patients who have experienced internuclear ophthalmoplegia. For each patient, it is determined whether a diagnosis of multiple sclerosis was established or not.
结局指标
主要结局
Analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis.
时间窗: 1 year
Proportion of patients with isolated internuclear ophthalmoplegia who converted to multiple sclerosis during follow-up.
次要结局
未报告次要终点