Intraductal Secretin Stimulation Test: What Is the Proper Collection Time?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Secretory flow rates measured by volume
研究概览
简要总结
The aim is to evaluate the peak secretory flow rates and bicarbonate concentrations as determined by a 30 minute intraductal secretin stimulation test in patients with a low likelihood of pancreatic pathology and to compare these data to those obtained from our historical patients with suspected chronic pancreatitis. These will be patients in which inadvertent pancreatic cannulation occurs during therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for biliary indications . All study subjects will receive a 5 day follow-up phone call. Enrollment goal is 36 subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female patients ≥ 18 years of age referred to Indiana University Health, University Hospital for ERCP for a biliary indication, at the discretion of the treating MD (e.g. suspected common bile duct stone, initial post-liver transplant evaluation, suspected or confirmed cholangiocarcinoma, suspected primary sclerosing cholangitis -- see exclusion criterion #12)
排除标准
- •Pregnant woman or breast feeding
- •Age <18 years
- •Patient unable to give informed consent
- •Patient with a history of pancreatic surgery
- •Patient with a history of pancreatic cancer
- •Patient with a history of acute or chronic pancreatitis
- •Patient with radiographic evidence of acute or chronic pancreatitis on CT, MRCP, or EUS
- •Patient with a current or prior history of average daily alcohol consumption of greater than 60 g per day for more than 2 years
- •Patient with a history of cigarette smoking greater that 20 pack-years
- •Patient with a history of pancreas divisum
- •Evidence of chronic pancreatitis on pancreatogram during ERCP
- •ERCP for an isolated biliary indication with previous biliary sphincterotomy or for biliary stent exchange, when pancreatic entry should easily be avoided by the endoscopist.
- •History of allergy or adverse reactions to secretin
结局指标
主要结局
Secretory flow rates measured by volume
时间窗: 30 minutes
Volume of pancreatic juices will be collected
Bicarbonate concentration of timed pancreatic juice
时间窗: 30 minutes
Concentration of bicarbonate levels will be determined
次要结局
未报告次要终点
研究者
Evan Fogel
Professor of Medicine
Indiana University