The Role of Autoimmune Mechanisms in the Pathogenesis of Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Cytokines Levels
研究概览
简要总结
This research study is being done to find out whether autoimmune mechanisms are associated with the development of atrial fibrillation.
详细描述
The study sets out to identify an explanation for the pathogenesis of AF, potentially forming the basis for designing novel targeted therapies to prevent or reverse this prevalent human disease. The overall objectives are to determine whether autoimmune diseases are associated with AF development and to identify specific diagnostic and prognostic biomarkers that will improve the ability to accurately predict risk of AF development. The study will prospectively enroll patients with and without AF and determine their serum cytokine levels and assess the functional responses of T cells on the basis of cytokine production after in vitro T-cell specific stimulation, using Luminex bead-based multiplex technology.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cases: AF (Persistent, paroxysmal AF)
- •Controls 1: (No prior history of AF or inflammatory or autoimmune diseases)
- •Controls 2: (biopsy proven Psoriasis)
排除标准
- •Clinically apparent acute infections over the past 4 weeks
- •Chronic infections
- •Recent malignancies
- •Recent Radiation or chemotherapy
- •Chronic kidney disease (≥ stage 2)
- •Organ transplantation
- •History of chronic liver disease
- •Major surgery or invasive procedure in the past 6 months
- •Internal prosthesis
- •Receiving immunosuppressive therapy
- •Known rheumatologic diseases (except for the participants with psoriasis)
- •Females who are known to be pregnant
结局指标
主要结局
Cytokines Levels
时间窗: through study completion, approximately 3 years.
Cytokine Profiles
次要结局
未报告次要终点