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临床试验/NCT05548530
NCT05548530招募中不适用

Analysis of Related Factors of Hematoma Morphology in Patients With Cerebral Hemorrhage and Prognosis Analysis of Different Regimens for Cerebral Hemorrhage

The Affiliated Hospital Of Guizhou Medical University1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2014年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
1,000
试验地点
1
主要终点
90-day Modified Rankin Rating Scale score;

研究概览

简要总结

To analyze the influence of early hematoma morphology on hematoma expansion, optimize the treatment plan for cerebral hemorrhage, and guide the treatment of patients with cerebral hemorrhage in combination with clinical practice.

详细描述

Intracerebral hemorrhage refers to the hemorrhage caused by the rupture of blood vessels in the non-traumatic brain parenchyma, accounting for 20% to 30% of all strokes, with an acute mortality rate of 30% to 40%. Different degrees of movement disorders, language disorders, etc. will be left behind. It is of great clinical significance to deeply explore the relevant factors and effective treatment plans for the evolution of cerebral hemorrhage. 30% of hematomas can still have active bleeding within 20 hours of onset. The INTERACT test defines hematoma expansion as 24-48 hours of repeated non-enhanced CT. The increase in hematoma volume >12.5ml or 33% of the original volume is the cause of neurological deterioration and abnormality. An important cause of poor prognosis, studies have confirmed that irregular hematoma morphology is a strong predictor of hematoma expansion. Treatment of cerebral hemorrhage currently includes medical treatment and surgical treatment. Surgical treatment has become an important method for the treatment of ICH due to its advantages of rapid removal of hematoma, relief of high intracranial pressure, and release of mechanical compression. However, whether surgery can reduce the mortality of patients with cerebral hemorrhage and improve neurological damage is still controversial. Surgical operations include dstereotactic intracranial hematoma puncture and drainage, decompressive craniectomy , neuroendoscopic. Currently, there are large randomized controlled trials at home and abroad on minimally invasive hematoma evacuation. The treatment of spontaneous intracerebral hemorrhage is safe, but the effectiveness of minimally invasive surgery is unclear due to inconsistent bleeding volume, surgical trauma, and hematoma morphology.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age 18-80 years old;
  • Intracerebral hemorrhage was diagnosed by head CT examination;

排除标准

  • Multiple intracranial hemorrhage;
  • Intracranial hemorrhage caused by intracranial tumor, aneurysm, trauma, infarction or other lesions;
  • Coagulation disorders or a history of taking anticoagulants;
  • Infectious meningitis, systemic infection;
  • History of severe stroke, heart, kidney, liver and lung dysfunction in the past;
  • Severe brain herniation (mydriasis, respiratory and circulatory failure);
  • Incomplete or missing basic data or follow-up information in the hospital.

结局指标

主要结局

90-day Modified Rankin Rating Scale score;

时间窗: 90-day

Modified Rankin Rating Scale score at 90 days after discharge,0-3 indicates good prognosis, 4-6 indicates poor prognosis, and 6 indicates death.

Hematoma expansion rate 24 hours after onset

时间窗: 24 hours of onset

The number of cases with enlarged hematoma after re-examination of head CT after 24 hours

次要结局

  • 90-day mortality(90-day)

研究者

发起方
The Affiliated Hospital Of Guizhou Medical University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Zhaoxu,MD

Principal Investigator

The Affiliated Hospital Of Guizhou Medical University

研究点 (1)

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