The Burden of COVID-19 Survivorship: Exercise Therapy to Combat the Sequelae of COVID-19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Maximal oxygen update (VO2max) measured in mL/kg/min
研究概览
简要总结
This research study is being done to find out what the longer-term physiological consequences of COVID-19 are, and to determine if exercise therapy can help improve lung function, heart function and overall fitness, and reduce symptoms in people recovering from SARS-CoV-2.
详细描述
The purpose of this research is to see if taking part in structured exercise training will improve the ability to exercise, the function of the lungs and the function of the heart, and reduce symptoms of fatigue and breathlessness in people recovering from COVID-19. After enrollment all patients will complete exercise testing, lung function testing, and cardiac imaging. Patients will be randomized to either 8 weeks of exercise training (4-5 times per week) or will continue standard medical care. All patients will undergo detailed exercise testing, lung function testing, and cardiac imaging after the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 21 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 21 to 75 years.
- •History of RT-PCR proven SARS-CoV-2 infection.
- •Deemed 'recovered' from SARS-CoV-2 infection.
- •Not clinically obese (BMI ≥ 36) and/or suffer from musculoskeletal or other conditions that would limit exercise participation.
- •No evidence of cardiac ischemia at rest or during exertion (via ECG).
- •Able to provide written informed consent.
排除标准
- •Individuals less than 21 or more than 75 years old.
- •Not able to take part in structured exercise training due to injury or other conditions that would put person at risk during exercise.
- •Unable to provide written informed consent.
结局指标
主要结局
Maximal oxygen update (VO2max) measured in mL/kg/min
时间窗: 8 weeks
VO2max is the maximal oxygen consumed during an exhaustive exercise test
次要结局
- Right ventricular contractile function measured as % fractional area change (RV FAC)(8 weeks)
- Forced vital capacity (FVC) measured in L(8 weeks)
- Forced expiratory volume in 1 second (FEV1) measured in L(8 weeks)
- Maximal inspiratory pressure (MIP) measured in cmH2O(8 weeks)
- Peak exercise work rate (Wpeak) measured in Watts(8 weeks)
- Left ventricular contractile function measured as % fractional area change (LV FAC)(8 weeks)
- Maximal expiratory pressure (MEP) measured in cmH2O(8 weeks)