Metabolomic Analysis of Body Fluid of Medulloblastoma in Children Based on New Mass Spectrometry and Its Application in Clinical Diagnosis and Recurrence Monitoring
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Metabolic marker(Uracil in Da)
研究概览
简要总结
Based on a new mass spectrometry system, body fluid samples were analyzed to verify the role of metabolite analysis in the diagnosis of pediatric medulloblastoma.
详细描述
Screening specific molecular metabolic markers for medulloblastoma after radiotherapy can improve the prediction of clinical diagnosis and prognosis of patients.The purpose of this study is to validate the role of metabolite analysis in the diagnosis of pediatric medulloblastoma based on the analysis of body fluid samples by a new mass spectrometry system.Based on the metabolic markers found by screening, the pathogenic mechanism of metabolic pathway blockade was explained, and the scientific basis for later treatment was put forward.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 3 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The samples are previous biological sample database data;
- •Sample collection time was 2017.05-2019.05;
- •The patient's age is over 3 years old;
- •KPS score ≥50 at the first diagnosis;
- •The patient was a medulloblastoma patient who had received surgical treatment and had not received radiotherapy or chemotherapy before.
排除标准
- •Recurrent patients;
- •Patients suffered from other malignant tumors during radiotherapy;
- •The body fluid samples or related clinical data are not perfect;
- •Storage failure of body fluid samples such as lipid dissolution and hemolysis occurred.
结局指标
主要结局
Metabolic marker(Uracil in Da)
时间窗: Changes of expression profiles of specific metabolic markers before and after radiotherapy,up to 3 months.
1. By comparing the expression of small molecule metabolites in body fluids between normal control group and patients with medulloblastoma before radiotherapy, to find specific markers. 2. To evaluate the expression of this metabolic marker in medulloblastoma patients before and after radiotherapy.
Metabolic marker(4-Hydroxyproline in Da)
时间窗: Changes of expression profiles of specific metabolic markers before and after radiotherapy,up to 3 months.
1. By comparing the expression of small molecule metabolites in body fluids between normal control group and patients with medulloblastoma before radiotherapy, to find specific markers. 2. To evaluate the expression of this metabolic marker in medulloblastoma patients before and after radiotherapy.
Metabolic marker(Glutamic acid in Da)
时间窗: Changes of expression profiles of specific metabolic markers before and after radiotherapy,up to 3 months.
1. By comparing the expression of small molecule metabolites in body fluids between normal control group and patients with medulloblastoma before radiotherapy, to find specific markers. 2. To evaluate the expression of this metabolic marker in medulloblastoma patients before and after radiotherapy.
Metabolic marker(Creatine in Da)
时间窗: Changes of expression profiles of specific metabolic markers before and after radiotherapy,up to 3 months.
1. By comparing the expression of small molecule metabolites in body fluids between normal control group and patients with medulloblastoma before radiotherapy, to find specific markers. 2. To evaluate the expression of this metabolic marker in medulloblastoma patients before and after radiotherapy.
次要结局
未报告次要终点