Prospective feasibility study of stereotactic arrhythmia radioablation

niversitair medisch centrum Utrecht0 个研究点目标入组 11 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

•1.Patient must be >18 years old
•2.Patient must have therapy refractory VT.
•Patient must have failed or become intolerant to at least one antiarrhythmic medication and one invasive catheter ablation procedure or invasive catheter ablation is not possible due to a contraindication (e.g. unfit for general anaesthesia, severe pulmonary disease).
•3. Cardiomyopathy, Ischemic or non-ischemic.
•4. Patients must have transvenous ICD
•5. Patients must have ICD information before study treatment

•1.Prior radiotherapy treatment above 30 Gy of the current treatment region
•2.Patients must not be pregnant or lactating
•3.NYHA class 4
•4.Extreme arrhythmia substrate:
•a.Polymorphic VT/VF
•b.>3 distinct clinical VT morphologies
•c.>5 distinct induced VT morphologies during testing
•5.The radiotherapy target volume must be suitable for stereotactic radiation.
•6.MRI criteria:
•a.claustrophobia
•b.non-MRI compatible according to https://richtlijn.mijnumc.nl/Beeld/MRI/Documents/Vragenlijst%20MRI-onderzoek%20volwassenen.pdf
•7.GFR above 30 ml/min
•8.Within one year after heart surgery or placing of an artificial heart valve

发起方

niversitair medisch centrum Utrecht