NCT02767960已完成不适用
Change of Serum Tenascin-C Concentration and the Relationship With Hs-CRP，cTnI and Prognosis in Patients With Acute Coronary Syndrome
The First Affiliated Hospital of Dalian Medical University1 个研究点 分布在 1 个国家目标入组 183 人开始时间: 2016年5月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 183
- 试验地点
- 1
- 主要终点
- Serum Tenascin-C concentration
研究概览
简要总结
This study valuates the serum Tenascin-C concentration in patients with acute coronary syndrome.
详细描述
It is found that Tenascin-C plays an important role in ventricular remodeling, heart failure, aortic dissection, rheumatic heart disease and other cardiovascular diseases, which may be a new marker for the diagnosis and prognosis prediction of these diseases. However, there is few relevant studies about the Tenascin-C concentration in patients with acute coronary syndrome.This study valuates the serum Tenascin-C concentration in patients with acute coronary syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •.diagnosed as acute coronary syndrome,including STEMI,non-STEMI,and UAP.
- •with left ventricular ejection fraction（LVEF）>=45%
- •written informed consents are obtained
- •admitted within 24 hours after chest pain attacked
排除标准
- •complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy
- •complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
- •with acute or chronic infection, surgery or trauma in the last month
- •secondary hypertension, severe liver dysfunction,severe renal insufficiency
- •with abnormal thyroid function or allergy to iodine agent
- •refusal to sign the informed consent
结局指标
主要结局
Serum Tenascin-C concentration
时间窗: 12 months
Serum Tenascin-C concentration in ng/ml
次要结局
- Relationship between Tenascin-C and high sensitive C reaction protein (hs-CRP) concentration(12 months)
- Relationship between Tenascin-C and Troponin-I (Tn-I) concentration(12 months)
- MACEs during 12-month follow-up(12 months)
研究者
Rchuang
Professor
The First Affiliated Hospital of Dalian Medical University
研究点 (1)
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