Optimizing the treatment of psoriasis with methotrexate; after 40 years the first dose-finding study. - DOME-study

Academisch Medisch Centrum0 个研究点目标入组 80 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•-Patients over 18 years old
•-Patients diagnosed with psoriasis
•-Patients who the treating dermatologist finds eligible for starting methotrexate therapy

•The exclusion criteria used are the contra-indications for treatment with MTX mentioned in the recently published Dutch guideline psoriasis:
•-men and women who are trying to conceive
•-pregnant or breastfeeding women
•-alcohol-or drug abuse
•-serious infections
•-immunodeficiency
•-bone-marrow dysfunction or haematological disorders
•-serious liver- or kidney function disturbance
•-a significantly low pulmonary function
•-ulcus ventriculi or duodeni
•-contra-indicated co-medication (hepatotoxic drugs like barbiturates, drugs that interfere with renal function like sulfomethoxazole, NSAID`s and penicilline or folic acid antagonists like trimethoprim.) ;Also patients with non plaque type psoriasis are excluded.

发起方