Basic Research Projects Related to Sports Injuries Such as Degenerative Osteoarthritis, Cruciate Ligament Injury, Patella Dislocation, Discoid Meniscus

I. Research Background In the "Twelfth Five-Year Plan for Biotechnology Development", the requirements for the construction of national biological science facilities are clearly put forward, and the construction of a national biological center, which includes the biological technology management information database and biological sample resource database.Biobank mainly refers to the standardized collection, processing, storage and application of biomacromolecules, cells, tissues and organs of healthy and disease organisms, including human organ tissues, whole blood, plasma, serum, biological fluid or processed biological samples (DNA, RNA, protein, etc.).Establish a standardized quality control, information management and application system for samples 1.In 1987 the American Institute of Cancer Research established a biobank of cancer samples.The UK Biobank was set up in 1999 to collect and closely monitor samples from 500,000 volunteers.At the same time, domestic and foreign research institutions are also jointly building and sharing biobanks.Europe, for example, has carried out genetic studies involving 520,000 people in 23 sample centers in 10 European countries.Human genetic resources are important strategic resources, China has a unique advantage of human genetic resources, effective protection and rational use of human genetic resources is very important.Proper collection of abundant and large sample resources is bound to provide great value for biological and medical research 3.

Sports medicine institute, Peking University third hospital is the largest sports medicine center, about 120000 m years MenZhenLiang, nearly 10000 years since, before the operation exsanguinate assay blood samples in laboratory tests, after the completion of the operation clean up the damage of tissue samples at the end of the surgery, for medical waste, by medical waste treatment, but the samples has high research value.From including morphological, genetic and molecular mechanism study 4-6, for sample tissue pathological slices, gene sequencing and other research methods to the field of sports medicine related diseases have a deeper understanding, and provide samples for future researchers reserve platform, to build samples of sports medicine institute library.

Sports injuries and joint structural abnormalities are multi-factor causes. Through the establishment of this project and the collection of intraoperative tissue, blood and saliva samples from patients with sports injuries, including degenerative osteoarthritis, admitted to the Institute of Sports Medicine of the Third Hospital of Beijing Medical University,To sample from the micro level of susceptibility genes and molecular signaling pathways to anatomical morphology and histopathologic study direction, and so on, can also for multiple transverse comparison research between samples, in order to investigate sports injury, including degenerative osteoarthritis pathogenesis, for sports trauma related disease etiology, diagnosis, treatment to provide new ideas and methods,And the selection of athletes, athletes special training plans, sports mode to provide more targeted suggestions.

II. Research Objectives

1. After the completion of the laboratory examination, the blood samples and tissue samples and body fluids discarded during the operation are retained for the purpose of building the "Basic Research Project on Sports Injuries Related to Degenerative Osteoarthritis, Cruciate Ligament Injury, Patella Dislocation, Discoid Meniscus and so on".
2. Use the samples of "Basic Research Project on Sports Injury Related to Degenerative Oosteoarthritis, Cruciate Ligament Injury, Patella Dislocation, Discoid Meniscus and Other Sports Injury" to conduct related research on the mechanism of sports injury, new treatment methods and treatment techniques to improve the efficacy.