KCT0000347已完成未知
A Phase II Trial of RAD001 (Everolimus) for 2nd Line Treatment After Failure of Fluoropyrimidine Plus Platinum Chemotherapy in Patients With Metastatic or Recurrent Gastric Cancer With pS6 Ser 240/4 Expression
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 45
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional Study
入排标准
- 年龄范围
- 20(Year) 至 75(Year)（—）
- 性别
- All
入选标准
- •Pathologically proven non-resectable adenocarcinoma of stomach with measurable disease
- •-Prior failure (progression during or within 6 months after) of 1st line palliative chemotherapy including fluoropyrimidine (capecitabine, S-1, or 5-FU) and platinum (cisplatin or oxaliplatin) for metastatic or recurrent gastric cancer
- •-High expression of pS6 Ser 240/4 (proportion of pS6 Ser 240/4 positive cancer cells by immunohistochemistry > 10%)
- •-Age 20 to 75 years old
- •-Estimated life expectancy of more than 3 months
- •-ECOG performance status of 2 or lower
- •-Adequate bone marrow function
- •-Adequate kidney function
- •-Adequate liver function
- •-Written informed consent
排除标准
- •- Other tumor type than adenocarcinoma
- •- Presence or history of CNS metastasis
- •- Obvious bowel obstruction or active gastrointestinal bleeding
- •- Other serious illness or medical conditions
研究者
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