NCT03361202Unknown不适用
Evolution of Microparticles Circulating Plasma Concentration in Atrial Fibrillation After Percutaneous Occluding of the Left Atrium With Prosthesis (Amplatzer® Cardiac Plug)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- levels of microparticles expressing phosphatidylserine in atrial fibrillation group
研究概览
简要总结
The aim of the study is to compare levels of differnts types of microparticles circulating before and after percutaneous occluding of the left atrium by patients with atrial fibrillation and patients control.
Hypothesis is that prothesis implantation will decrease levels of microparticles circulating in blood circulation because of occluding of the left atrium .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •atrial fibrillation group:
- •high embolic risk (CHADS-VASC2 score ≥4)
- •formal and final contraindication to anticoagulant therapy
- •no heart thrombus on ETO and TDM before percuraneous occluding
- •control group:
- •suspicion of stable coronary artery disease, coronary angiography scheduled and double platelet aggregation (clopidogrel and aspirine)
排除标准
- •for both groups
- •congestive heart failure, severe aortic stenosis, EP or TVP early.
结局指标
主要结局
levels of microparticles expressing phosphatidylserine in atrial fibrillation group
时间窗: 45 days after Percutaneous Occluding of the Left Atrium.
blood samples analized by flow cytometry
次要结局
未报告次要终点
研究者
研究点 (1)
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