NCT00870129招募中不适用
Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans: A Pilot Study, and to Examine Metabolite Changes in Gliomas and Other Solid Tumors
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- To assess the utility of baseline advanced MRI & changes between baseline & follow up advanced MRI in predicting high risk areas that are likely to develop progressive glioma despite chemoradiotherapy.
研究概览
简要总结
The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk of recurring. WeThe reserchers are doing this study to see whether this advanced imaging is a safe treatment that causes few or mild side effects in people with brain tumors.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspected or Histopathologically proven diagnosis of high grade or low glioma or tumor is suspected to harbor an isocitrate dehydrogenase (IDH) mutation
- •May undergo radiation therapy
- •Patient and/or guardian is able to provide written informed consent prior to study registration
- •Age ≥ 18 years old
排除标准
- •Extreme claustrophobia that precludes MRI scan
- •Known allergic reaction to Gd-DTPA
- •Any contraindication to gadolinium intravenous contrast as per standard Department of Radiology contrast guidelines
- •Any absolute contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander).
- •Pregnant or nursing female
- •Unable to cooperate for MRI and/or radiation therapy planning
结局指标
主要结局
To assess the utility of baseline advanced MRI & changes between baseline & follow up advanced MRI in predicting high risk areas that are likely to develop progressive glioma despite chemoradiotherapy.
时间窗: 1 -7 weeks before radiation treatment, about two months after treatment, and about every two months thereafter for the duration of the study.
次要结局
- feasibility of 2HG spectroscopy(2 years)
- To compare radiation therapy simulations in patients with gliomas using conventional and baseline advanced MRI data.(prior to and 1 months±3 weeks after radiation therapy.)
研究者
研究点 (1)
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