Biological and Biochemical Markers of Aneurysm Wall Degradation; Towards Non-Invasive Wall Strength Analysis.
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Aneurysm wall strength
研究概览
简要总结
The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.
详细描述
Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient scheduled for transabdominal aortic surgery
排除标准
- •Patient characteristics and aneurysm anatomy suitable for endovascular repair
- •Previous aortic surgery
结局指标
主要结局
Aneurysm wall strength
时间窗: Post-operative
次要结局
- Extra Cellular Matrix components (Glucoaminoglycans)(post-operative)
- Biochemical blood analysis(post-operative)
- MMP content(post-operative)
- Degree of inflammation(Post-operative)