Use of Tranexamic Acid in Postoperative Early Period Bleeding in Patients Undergoing Sleeve Gastrectomy: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- effect on bleeding in the first one hours postoperatively
研究概览
简要总结
The effectiveness of Tranexamic acid use will be measured in cases of sleeve gastrectomy in bariatric surgery and in early postoperative bleeding.
详细描述
Prospective, comparative and double-blind study with patients aged 18-65 years admitted to bariatric surgery. Selected patients were given or not given venous tranexamic acid (TXA) during anesthesia induction (CG). Anesthesia and thromboprophylaxis protocols were similar between groups. For statistical analysis, χ2 and analysis of variance tests were performed using the SPSS 21.0 ® statistical program at a significance level of p < 0.05.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients aged 18 to 65 years with an American Association of Anesthesiologists (ASA) physical condition score II or III
- •undergoing bariatric surgery and LSG
排除标准
- •history of thromboembolic disease or severe comorbidity (ASA IV or more)
- •platelet antiaggregants or anticoagulants
- •active intravascular coagulation carriers
- •acute occlusive vasculopathy
- •hypersensitivity to the components of the TXA formula.
结局指标
主要结局
effect on bleeding in the first one hours postoperatively
时间窗: postoperative 1st hours
postoperative bleeding
次要结局
- effect on bleeding in the first 24 hours postoperatively(postoperative 24st hours)
研究者
Medeni Şermet
Specialist Medical doctor
Goztepe Prof Dr Suleyman Yalcın City Hospital