Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Grooved pegboard test
研究概览
简要总结
The objective of the clinical trial is to evaluate the mediating influence of force control on the pegboard times of adults (50-89 years) who are stratified into groups of faster and slower pegboard times. The hypothesis is that practice of either a pegboard test or a force-control task will reduce pegboard times, but the decrease will be greater and less similar after the two practice interventions for the slower group of participants. The outcomes are expected to demonstrate that force control is a modifiable mediator of pegboard times for this cohort, but the effect will be stronger for the group with faster pegboard times.
详细描述
The study will involve a randomized, cross-over design with a one-week washout between arms. The two arms (3 weeks each) will comprise practice of the grooved pegboard test and practice of steady contractions while lifting and lowering light loads with a hand muscle. Randomization into practice order will be accomplished with a block approach (block size = 4) for each of the two groups. The outcome assessors will be blinded to practice order. The outcomes will comprise three tests of manual dexterity and the measurement of force control during submaximal contractions. The outcomes will be obtained before and after the six sessions in each practice arm.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to read, write, and speak English
- •Able to arrange transportation to the Boulder campus
排除标准
- •Cognitive impairment
- •Major psychiatric condition
- •Unstable depressive disorder
- •Progressive neurological, muscular, cardiovascular, or skeletal disorder
- •Chronic pain condition
- •Currently taking medication known to influence neuromuscular function
- •Recent hospitalization
- •Unable to attend 12 practice sessions in 6 weeks
结局指标
主要结局
Grooved pegboard test
时间窗: Changes from baseline (week 1) at weeks 4 and 7
Time to complete the test as quickly as possible
Jebsen Hand Function test
时间窗: Changes from baseline (week 1) at weeks 4 and 7
Time to complete the test as quickly as possible
9-hole pegboard test
时间窗: Changes from baseline (week 1) at weeks 4 and 7
Time to complete the test as quickly as possible
Force control
时间窗: Changes from baseline (week 1) at weeks 4 and 7
The coefficient of variation for force when subjects exert a constant submaximal force
次要结局
- MVC force(Changes from baseline (week 1) at weeks 4 and 7)
- Index finger acceleration(Changes from baseline (week 1) at weeks 4 and 7)
- Motor unit discharge rates(Changes from baseline (week 1) at weeks 4 and 7)
- EMG amplitude(Changes from baseline (week 1) at weeks 4 and 7)
- 1-RM load(Changes from baseline (week 1) at weeks 4 and 7)
研究者
Roger Enoka
Professor
University of Colorado, Boulder