Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Physical performance on 6-min walk test (6MWT)
研究概览
简要总结
The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.
详细描述
The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 <80% of predicted).
排除标准
- •failure to complete physical testing,
- •on-going participation in rehabilitation programs,
- •pacemaker or use of nicotine products,
- •oxygen mask,
- •beta blockers,
- •antibacterial mouthwash,
- •chewing gum or stomach-neutralizing medicine during the intervention.
研究组 & 干预措施
Placebo ---> Dietary beetroot
Placebo was administrated in the first period of the cross-over trial, while the intervention beverage Dietary Beetroot juice was administrated in the second period of the trial.
The placebo: was an NO3- negligble drink from James White Drinks England (Beet-it), which was otherwise similar to the dietary beetroot juice in nutrient composition, smell and appearance. Dose: 2x70 mL consumed twice a day for six days.
Intervention beverage, Dietary beetroot juice:Consumed as beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.
干预措施: Dietary beetroot juice (Dietary Supplement)
Dietary beetroot juice --> Placebo
The intervention beverage Dietary beetroot juice was administrated in the first period of the cross-over trial, while placebo was administrated in the second period of the trail Intervention beverage, Dietary beetroot juice:Consumed as beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days. The placebo: was an NO3- negligble drink from James White Drinks England (Beet-it), which was otherwise similar to the dietary beetroot juice in nutrient composition, smell and appearance. Dose: 2x70 mL consumed twice a day for six days.
干预措施: Dietary beetroot juice (Dietary Supplement)
结局指标
主要结局
Physical performance on 6-min walk test (6MWT)
时间窗: 6 minutes
次要结局
- Physical activity level(Six days)
- Oxygen consumption during submaximal cycling(Two trials of 6 minutes duration (10 min break between trials))
- Plasma Nitrite concentration(Baseline, 150 and 210 minutes after consumption of beverages)
- Blood Pressure(At baseline and 150 minutes after consumption of beverages)