An 8 Week, Randomized, Double-blind, Placebo-controlled Crossover Clinical Trial of Allium Hookeri Root Extract on Anti-diabetic Effects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- Changes of blood glucose during OGTT
研究概览
简要总结
The researchers investigated the anti-diabetic effects of Allium hookeri root extract for Korean prediabetic participants.
详细描述
Allium hookeri root is widely consumed as a vegetable and herbal medicine in Asia. Although the antidiabetic activities of Allium hookeri have been documented in animal studies, the improved effects of Allium hookeri on human are not clear. Therefore, in this study, the researchers investigated whether Allium hookeri root extract could be effective in reducing the risk of type 2 diabetes in individuals with prediabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fasting glucose 100~126 mg/dl
排除标准
- •Significant variation in weight (more 10%) in the past 3 months
- •Treatment by hypoglycemic and hypolipidemic drug therapy within the past three months
- •Type 1 diabetes or HbA1c>9.0%
- •Cardiovascular disease
- •Hypoglycemic agent, obesity medicine, and lipid lowering agent within past 6 months or blood sugar, obesity, and lipid improvement functional foods within past 2 monts
- •Pregnancy or breast feeding
研究组 & 干预措施
Allium hookeri extract
take two capsules per day (486 mg/day) for 8 weeks
干预措施: Allium hookeri extract (Dietary Supplement)
Placebo
take two capsules per day for 8 weeks
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Changes of blood glucose during OGTT
时间窗: 8 weeks
Changes of fasting and postprandial glucose during OGTT were assessed before and after the intervention
次要结局
- Changes of HbA1c(8 week)
- Changes of C-peptide(8 week)
- Changes of blood insulin(8 week)
研究者
Soo-Wan Chae
Principal Investigator, Clinical Trial Center for Functional Foods
Chonbuk National University Hospital