The Effect of High Flow Nasal Cannula on Exercise Capacity Compared to Venturi Mask in COPD Patients Recovering From Acute Evacerbation
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Endurance time
研究概览
简要总结
Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.
详细描述
We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •hospitalized AECOPD patients
- •be ambulatory by 48h after admission for AECOPD
- •requires oxygen by screening exercise test
排除标准
- •active coronary ischemia
- •respiratory diseases other than COPD
- •unstable vital signs
- •unstable psychological status
结局指标
主要结局
Endurance time
时间窗: 10 minute
Endurance time for 10 minute steping test
次要结局
- Respiratory pattern(10 minute)
- Work of breathing(10 minute)
- Neural respiratory drive(10 minute)
研究者
Shiying Fang
Principal Investigator
The First Affiliated Hospital of Guangzhou Medical University