Role of Oxytocin in Telling and Detecting Lies
试验速览
- 阶段
- 早期 1 期
- 状态
- 撤回
- 主要终点
- Unethical behavior
研究概览
简要总结
The investigators are interested in the impact of intranasal oxytocin in unethical behavior.
详细描述
The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior. Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons. It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion. In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •_____ _____BP > 130/85, HRT > 95 (can be included at discretion of study physician/designee)
- •_____History of seizures
- •_____Neurological Disorder
- •_____Current psychiatric disorder
- •_____Previous psychiatric disorder (can be included at discretion of PI)
- •Date last episode (if > 1 year, include; if <1 year, at discretion of PI)
- •_____Current use of psychoactive drugs
- •_____Previous use of psychoactive drugs (can be included at discretion of PI) _____Date last medicated_____ _____Type of medication___________________________________
- •_____Current use of anticoagulants
- •_____Current use of corticosteroids
- •_____Previous head trauma (can be included at discretion of PI)
- •_____Alcoholism or substance abuse
- •_____Carcinoma of the breast or prostate
- •_____Renal or Hepatic diseases
- •_____Chronic lung diseases
- •_____Cancer
- •_____Liver problems
- •_____Hypertension/Cardiac diseases
- •_____Cardiovascular Disease
- •_____Nephritis
- •_____Diabetes (use of insulin) /Obesity
- •_____Endocrine disease or malignancy
- •_____Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
- •Medication
- •Frequency of episodes____ _____Date of last episode_____
- •_____Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
- •Medication _____Frequency of migraines_____ _____Date of last migraine_____
- •_____High levels of physical contact with women or children
研究组 & 干预措施
oxytocin
Intranasal 24 IU oxytocin self-administration.
干预措施: Oxytocin (Drug)
placebo
Intranasal placebo. 125 mg of 0.5% cholorobutanol to 50 ml saline, with approximately 5 pH. The solution will then be sterilized using a 0.22 micron filter.
干预措施: Oxytocin (Drug)
结局指标
主要结局
Unethical behavior
时间窗: 130 minutes
To measure unethical behavior, we will calculate whether participants took more money than they actually earned on a problem-solving task.
次要结局
未报告次要终点