Determinants of Muscle Strength in Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 5
- 主要终点
- Voluntary muscle strength evaluated by handheld dynamometer
研究概览
简要总结
Aim of this study is to determine in chronic kidney disease patients:
- the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment
- the relationship between voluntary muscle strength and muscle mass
- the relationship between voluntary muscle strength and lean body mass
- the correlation between voluntary muscle strength and physical activity
详细描述
Aim of this study is to determine in chronic kidney disease patients:
- the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer)
- the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index)
- the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis)
- the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the "Voorrips" score questionnaire)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months
- •stable clinical condition (absence of infection, stroke or acute decompensation)
排除标准
- •chronic kidney disease without extrarenal replacement therapy
- •history of renal transplantation
研究组 & 干预措施
Muscle strength
single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by "Voorrips" score questionnaire), inflammatory and nutritional status.
干预措施: Creatinine index (Biological)
Muscle strength
single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by "Voorrips" score questionnaire), inflammatory and nutritional status.
干预措施: Electrical bioimpedance analysis (Device)
Muscle strength
single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by "Voorrips" score questionnaire), inflammatory and nutritional status.
干预措施: Handheld dynamometer (Device)
Muscle strength
single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by "Voorrips" score questionnaire), inflammatory and nutritional status.
干预措施: "Voorrips" score questionnaire (Other)
Muscle strength
single evaluation (the day of inclusion) of muscle strength (by handheld dynamometer), muscle mass (by creatinine index estimation), lean body mass (by electrical bioimpedance analysis), physical activity (by "Voorrips" score questionnaire), inflammatory and nutritional status.
干预措施: Inflammatory and nutritional status (Biological)
结局指标
主要结局
Voluntary muscle strength evaluated by handheld dynamometer
时间窗: 1 day
data will be measured in Newton.meter
次要结局
- Lean body mass evaluated by electrical bioimpedance analysis(1 day)
- Physical activity estimated using the "Voorrips" score questionnaire(1 day)
- C reactive protein level(1 day)
- Albumin level(1 day)
- Muscle mass estimated by creatinine index evaluation(1 day)