Heart Rate Variability and Its Association With Symptom of Orthostatic Hypotension in Spinal Cord Injury
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Logistic regression analysis of heart rate variability variables according to OH and presence of symptom
研究概览
简要总结
In this study, the SCI patients were sub-grouped on the basis of symptoms into symptomatic and asymptomatic groups and measured HRV during resting and tilt up tests to compare their cardiovascular autonomic functions.
详细描述
In study protocol and the subjects were asked to lie down quietly for 5 minutes, closing their eyes and avoiding talking, moving hand, legs and body, and coughing during the test. R-R interval and blood pressure were measured beat-to-beat using Finometer® PRO (Finapres Medical Systems, Amsterdam, Netherlands) for 6 minutes each in two positions, supine and 60-degree angle on the tilt table.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •spinal cord injury with or without OH
- •aged 19 or older
- •ASIA Impairment Scale (AIS) A to D
- •neurological level of injury above T6.
排除标准
- •Those with heart and respiratory diseases, neurological diseases other than SCI - medically unstable states
- •Those who are taking medications affecting BP that cannot be stopped
结局指标
主要结局
Logistic regression analysis of heart rate variability variables according to OH and presence of symptom
时间窗: at the test time (15minutes)
the investigators conducted logistic regression analysis to evaluate the significance and impact of HRV variables associated with orthostatic hypotension and its symptoms in spinal cord injury patients.
Differences of heart rate variability between groups (OH vs non-OH, asymptomatic-OH vs symptomatic-OH group)
时间窗: at the test time (15minutes)
mean HR (heart rate), mean RR(RR interval), RMSSD (mean square of the successive R-R interval differences), SDNN (standard deviation of normal-to-normal interval), LF (low frequency) domain, HF(High frequency) domain
次要结局
未报告次要终点
研究者
Hae-ri Park
doctor
Pusan National University Yangsan Hospital