A Comparison of Gut Microbiome Profiles in Relation to Cognition and Neuroplasticity across Ageing and Parkinson’s disease

Helen Macpherson0 个研究点目标入组 144 人开始时间: 2021年1月8日最近更新: 2021年1月18日

适应症

试验速览

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•50-80 years for both groups (Healthy older and PD groups) and between 18-35 years for the healthy younger adult group
•Presence of PD, as determined through independent neurologist, for PD group. Level of severity (UPDRS stage II and III) will be determined and mild-moderate PD patients will be included. Note: No early onset PD cases to be included in the study, PD diagnosis has to have occurred at 50 years of age or later.
•For healthy older group, no neurological conditions present and no first-degree relatives with PD (determined through self-report questionnaires). No signs of Parkinsonism or symptoms associated with premotor PD (Assessed through the Unified Parkinson’s Disease Rating Scale (UPDRS stages II and III)
•greater than or equal to 24/30 for the healthy older group on the Montreal Cognitive Assessment (MoCA), greater than or equal to 21 for the PD group on the MoCA
•For the healthy younger adult group:
•Aged between 18-35 years
•No neurological/neurodegenerative conditions and no first-degree relatives with PD (determined through self-report questionnaires)
•No signs of Parkinsonism or symptoms associated with premotor PD (Assessed through the Unified Parkinson’s Disease Rating Scale (UPDRS stages II and III)
•greater than or equal to 24/30 on the MoCA

•Taken prebiotics (fibre supplementation, inulin etc.) or probiotics (Over the counter probiotics, , including Yakult or similar products) within previous 3 months
•Gastrointestinal diseases such as Colitis or Crohn’s disease
•Obesity (BMI greater or equal to 30)
•Drugs/Medication including proton-pump inhibitors and antibiotic use (within the previous 3 months)
•Current drug or alcohol abuse
•Conditions precluding TMS (epilepsy, pacemakers, metal implants etc.)
•PD individuals excluded if they have atypical or secondary Parkinsonism. Additional neurological conditions (i.e. stroke, epilepsy etc. will also be exclusions)
•Clinical diagnosis of depression, or a score of greater than 21 (21-30 indicates moderate depression) as assessed through Beck’s Depression Inventory

发起方

Helen Macpherson