The Novel Use of Prophylactic Noradrenaline Infusion and Its Impact on Post-induction Hypotension in Patients With Surgical Sepsis, a Double Blind Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Incidence of post induction hypotension in both groups
研究概览
简要总结
researchers aim to evaluate the influence of prophylactic noradrenaline infusion on post-induction hypotension
详细描述
If post-induction hypotension is not addressed promptly, it can lead to severe complications such as reduced blood flow, acute kidney damage, and myocardial ischemia. As a result, early detection and proactive intervention are crucial. Researchers of the current study decided to investigate impact of noradrenaline administered as a prophylaxis on post induction hypotension
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with sepsis undergoing source control surgery.
排除标准
- •Patient refusal
- •Patient with cardiac pathology ( ischemic heart disease or heart failure)
- •Preoperative hemodynamic instability (defined as MAP < 65 mmHg)
- •Rapid sequence induction
研究组 & 干预措施
Noradrenaline
Noradrenaline will be infused at a fixed rate of 0.2 mic/kg/min at 5 minutes before induction
干预措施: Noradrenaline 0.2 mcg/kg/min at 5 minutes before induction (Drug)
结局指标
主要结局
Incidence of post induction hypotension in both groups
时间窗: Within the first 10 minutes of induction.
Hypotension will be considered if MAP\< 65 mmHg
次要结局
- Incidence of acute kidney injury(7 days post operative)
- Incidence of myocardial infarction(7 days postoperative)
- Incidence of stroke(7 days postoperative)
研究者
Mina Adolf Helmy
Lecturer of anesthesia and critical care
Cairo University