Response of Alkylresorcinols and Other Biomarkers to Different Cereals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Plasma Alkylresorcinol Compounds
研究概览
简要总结
Cereal grains contain a wide variety of different phytochemicals which may play different roles in physiology. Their response in plasma and urine after a meal is poorly defined for most cereals. This study will investigate the plasma response and urinary excretion of cereal compounds after eating 6 different types of cereal preparation, with a focus on alkylresorcinols.
详细描述
This was a cross-over, randomized, double blind study with 6 arms (flours of different composition). Thirteen subjects completed the trial, where 100 g of each flour, mixed with 300 mL milk, was fed to all subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal-overweight (BMI 19-28 kg/m2)
- •Non-smokers
排除标准
- •Regular consumers of wholegrain cereals
- •Allergy to cereal or milk products
研究组 & 干预措施
Refined wheat flour
A negative control flour to serve as a reference.
干预措施: Esterase wholegrain wheat flour (Other)
Refined wheat flour
A negative control flour to serve as a reference.
干预措施: Wholegrain wheat flour (Other)
Refined wheat flour
A negative control flour to serve as a reference.
干预措施: Liquid whole grain wheat flour (Other)
Refined wheat flour
A negative control flour to serve as a reference.
干预措施: Wholegrain barley flour (Other)
Refined wheat flour
A negative control flour to serve as a reference.
干预措施: Liquid wholegrain barley flour (Other)
Esterase wholegrain wheat flour
Wholegrain wheat flour treated with esterases to release phenolics (positive control for phenolic acids)
干预措施: Refined wheat flour (Other)
Esterase wholegrain wheat flour
Wholegrain wheat flour treated with esterases to release phenolics (positive control for phenolic acids)
干预措施: Wholegrain wheat flour (Other)
Esterase wholegrain wheat flour
Wholegrain wheat flour treated with esterases to release phenolics (positive control for phenolic acids)
干预措施: Liquid whole grain wheat flour (Other)
Liquid whole grain wheat flour
Test flour with unknown response.
干预措施: Wholegrain barley flour (Other)
Esterase wholegrain wheat flour
Wholegrain wheat flour treated with esterases to release phenolics (positive control for phenolic acids)
干预措施: Wholegrain barley flour (Other)
Esterase wholegrain wheat flour
Wholegrain wheat flour treated with esterases to release phenolics (positive control for phenolic acids)
干预措施: Liquid wholegrain barley flour (Other)
Wholegrain wheat flour
Flour with unknown response
干预措施: Refined wheat flour (Other)
Wholegrain wheat flour
Flour with unknown response
干预措施: Esterase wholegrain wheat flour (Other)
Wholegrain wheat flour
Flour with unknown response
干预措施: Liquid whole grain wheat flour (Other)
Wholegrain wheat flour
Flour with unknown response
干预措施: Wholegrain barley flour (Other)
Wholegrain wheat flour
Flour with unknown response
干预措施: Liquid wholegrain barley flour (Other)
Liquid whole grain wheat flour
Test flour with unknown response.
干预措施: Refined wheat flour (Other)
Liquid whole grain wheat flour
Test flour with unknown response.
干预措施: Esterase wholegrain wheat flour (Other)
Liquid whole grain wheat flour
Test flour with unknown response.
干预措施: Wholegrain wheat flour (Other)
Liquid whole grain wheat flour
Test flour with unknown response.
干预措施: Liquid wholegrain barley flour (Other)
Wholegrain barley flour
Test flour with unknown response.
干预措施: Refined wheat flour (Other)
Wholegrain barley flour
Test flour with unknown response.
干预措施: Esterase wholegrain wheat flour (Other)
Wholegrain barley flour
Test flour with unknown response.
干预措施: Wholegrain wheat flour (Other)
Wholegrain barley flour
Test flour with unknown response.
干预措施: Liquid whole grain wheat flour (Other)
Wholegrain barley flour
Test flour with unknown response.
干预措施: Liquid wholegrain barley flour (Other)
Liquid wholegrain barley flour
Test flour with unknown response.
干预措施: Refined wheat flour (Other)
Liquid wholegrain barley flour
Test flour with unknown response.
干预措施: Esterase wholegrain wheat flour (Other)
Liquid wholegrain barley flour
Test flour with unknown response.
干预措施: Wholegrain wheat flour (Other)
Liquid wholegrain barley flour
Test flour with unknown response.
干预措施: Liquid whole grain wheat flour (Other)
Liquid wholegrain barley flour
Test flour with unknown response.
干预措施: Wholegrain barley flour (Other)
结局指标
主要结局
Plasma Alkylresorcinol Compounds
时间窗: From 0 to 48 h post dose.
Area under the curve (AUC) over baseline of alkylresorcinol compounds are measured for the 6 interventional arms. Time points are: t = 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 14, 24 and 48 h after product intake.
次要结局
- Phenolic Acids(0-48 h post dose)
- Plasma and Urinary Betaine(From 0 to 48 hours post dose)
研究者
CDUuser
MD, PhD
Société des Produits Nestlé (SPN)