Is the Weighted Genetic Risk Score Associated With Dupuytren Disease Recurrence?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 427
- 试验地点
- 1
- 主要终点
- Presence of recurrent Dupuytren disease
研究概览
简要总结
Rationale: Retrospectively reviewing the participants of the GODDAF database, revealed a significant association between the weighted genetic risk score and Dupuytren disease recurrence. However, a significant dose-response relation was not found. This might be caused by underestimating the recurrence rate, due to the retrospective nature of determining recurrence. Therefore, we want to do a follow-up measurement of the GODDAF participants, to see whether they suffered from recurrent disease.
Objective: We aim to determine whether the wGRS is associated with recurrent DD.
Study design: An observational study, in which the participants of the GODDAF study are followed up.
Study population: Patients affected by Dupuytren disease, aged 18-96 years, who were previously included in another study on the genetic basis of Dupuytren disease.
Intervention (if applicable): NA Main study parameters/endpoints: The main study parameter is the presence of recurrent Dupuytren disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DD patient
- •participant in the GODDAF study
- •genetic data passed the quality control
- •surgical treatment of DD
- •written informed consent
排除标准
- •Decisionally incapacitated
- •Patients treated for DD with collagenase or radiotherapy
结局指标
主要结局
Presence of recurrent Dupuytren disease
时间窗: 1 day
there is only one measurement in this study
次要结局
- Severity of Dupuytren recurrence(1 day)
研究者
D.C. Broekstra
MSc
University Medical Center Groningen