Role of different phosphate binders on absorption of vitamin K, metabolism of matrix γ-carboxy-glutamaat (Gla) proteïne (MGP)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 16
研究概览
简要总结
1 Arterial media calcification in end stage renal disease: impact on all cause and cardiovascular mortality. London GM, Guerin AP, Marchais S.J, et al. Nephrol Dial Transplant. 2003 Sept; 18(9): 1731-40.
2 Braun J, Oldenhof M, Moshage W, et al.Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients. Am J Kidney Dis. 1996 Mar; 27(3): 294-401.
3 Goodman W.G, Goldin J, Kuizon B.D, et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med. 2000 May; 342 (20): 1478-83.
4 Chertow GM, Burke SK, Raggi P. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int. 2002 jul; 62 (1): 245-52. 5 McCullough P.A, Sandberg K.R, Dumler F, Yanez J.E. Determinants of coronary vascular calcification in patients with chronic kidney disease and end-stage renal disease: a systematic review. J Nephrol. 2004 Mar-Apr; 17(2): 205-15.
6 Moe SM, O’Neill KD, Reslerova M, et al. Natural history of vascular calcification in dialysis and transplant patients. Nephrol Dial Transplant. 2004; 19: 2387-93.
7 Luo G,Ducy P, McKee MD, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein.Nature 1997; 386: 78-81.
8 Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov; 134(11): 3100-5.
9 Furie, B, Bouchard, B, Furie, BC.Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid. Blood 1999; 93:1798.
10 Davie, EW. Biochemical and molecular aspects of the coagulation cascade.ThrombHaemost 1995; 74:1.
11 Francucci CM, Ceccoli L, Rilli S, et al. Skeletal effects of oral anticoagulants. J Endocrinol Invest.2009; 32(4 Suppl): 27-31.
12 Schurgers LJ, Barreto DV, Barreto FC, et al. The circulating Inactive form of MGP is a surrogate marker for vascular calcification in chronic kidney disease: A preliminary report. J Am SocNephrol. 2010 Apr; 5(4): 568-75.
13 Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004 Nov; 134(11): 3100-5.
14 Krueger T, Westenfeld R, Ketteler M, Schurgers LJ, Floege J. Vitamin K deficiency in CKD patients, a modifiable risk factor for vascular calcification. Kidney International 2009; 76: 18–22.
15 Westenfeld R, Krueger T, Schlieper G, et al. Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis.2012 Feb; 59(2):186-95.
16 Koos R, Mahnken AH, Muhlenbruch G, et al. Relation of oral anticoagulation to cardiac valvular and coronary calcium assessed by multislice spiral computed tomography. Am J Cardiol 2005; 96: 747-749.
17 Takagi K, Masuda K, Yamazaki M, et al. Metal and ion and vitamin adsorption profiles of phosphate binder ion-exchange resins. Clin. Nephrol. 2010 Jan; 73(1): 30-5.
18 Sevelamer Summary Product information.
19 Pierce D, Hossack S, Poole L, et al.The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol.Nephrol. Dial. Transplant. 2011 May; 26(5): 1615-21.
20 Block GA, Wheeler DC, Persky MS, et al. Effects of phosphate binders in moderate CKD. J. Am. Soc. Nephrol 2012 Aug; 23(8): 1407-15.
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •Haemodialysis patients aged 18 years or above without the prospect of renal function recovery, planned renal transplantation, and life expectancy longer than six months.
排除标准
- •1 Use of vitamin K antagonists
- •2 Calcium under 2,1 mmol/l or above 2,6 mmol/l, after correction for albumin level
