NCT04706065Unknown不适用
Genetic Polymorphisms of Serine Hydroxylmethyl Transferase 1 (SHMT1) in Patients With Parkinson's Disease
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- polymorphism of SHMT1gene
研究概览
简要总结
Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system . SHMT has been shown to be associated with various diseases.
详细描述
This case -control observational prospective study will conducted on 40 patients with PD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients age ≥ 50 years.
- •Patients with PD diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UK PDS Brain Bank diagnostic criteria)
排除标准
- •Patients with parkinsonian plus syndrome
- •Patients with secondary parkinsonism
- •Patients with other chronic comorbidities (renal, hepatic, and endocrinal disturbances and chronic chest disease.)
- •Past and /or present history of epilepsy.
- •Patients with disturbed conscious level.
结局指标
主要结局
polymorphism of SHMT1gene
时间窗: one year
次要结局
- the role of SHMT1plymorphism in pathogenesis PD(one year)
- Study the relationship of Shmt1 polymorphism to the severity of Parkinson disease(One year)
研究者
Effat AETony, MD
professor of internal medicine
Assiut University
研究点 (1)
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