NCT03088163Unknown不适用
The Value of DWI-MRI(Diffusion-weighted Imaging) in Evaluating the Early Efficacy of Liver Metastasis in Colorectal Cancer
适应症
干预措施
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Response rate
研究概览
简要总结
The study is designed to evaluate the value of DWI-MRI (Diffusion weighted magnetic resonance imaging) in predicting the efficacy of liver metastases after chemotherapy in colorectal cancer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged ≥18 years with histologically or cytologically confirmed advanced colorectal adenocarcinoma
- •Eastern Cooperative Oncology Group performance status of 0 to 2
- •life expectancy of ≥ 3 months
- •at least one measurable liver metastatic lesion in MRI (≥10mm)
- •have adequate bone marrow, hepatic, and renal function
- •previously received no palliative chemotherapy
排除标准
- •patients with previous chronic inflammatory bowel disease, chronic diarrhea or recurrent bowel obstruction
- •patients with symptomatic brain metastases
- •active clinical severe infection
- •have contraindication of MRI screening
研究组 & 干预措施
DWI-MRI
Experimental
干预措施: Diffusion weighted magnetic resonance imaging (Device)
结局指标
主要结局
Response rate
时间窗: 2 months
the response rate predicted by DWI-MRI
次要结局
- Progression free survival(2 months)
- Overall survival(2 months)
研究者
Weijian Guo
Fudan University Shanghai Cancer Center
Fudan University
研究点 (1)
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