Clinical and Histopathological Evaluation of 41 Cases of Pediatric Granuloma Annulare
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Evaluation of the ages of the pediatric patients with granuloma annulare
研究概览
简要总结
INTRODUCTION: Granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. Although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. It is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study.
MATERIALS and METHODS: This study was performed retrospectively in a single-center, tertiary dermatology hospital. Forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Demographic characteristics, and clinical and histopathological features were evaluated.
详细描述
Granuloma annulare; is a non-infectious, granulomatous skin reaction with potential triggers that can affect the adult and pediatric age group. Diabetes mellitus, hyperlipidemia, and malignancy have been described in association with adult granuloma annulare cases. While there are studies on the clinical, pathological features and associated diseases in patients with adult granuloma annulare, a limited number of studies have been conducted on pediatric granuloma annulare patients. Therefore, clinical and histopathological evaluation of pediatric granuloma annulare cases was planned in our study.
This study was performed retrospectively in a single-center tertiary dermatology hospital. Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Cases with uncertain diagnosis were not included in the study. Cases with dermatological findings recorded in detail and/or diagnosed histopathologically were included in the study. Demographic features, lesion localization, lesion characteristics (size, elementary lesion, color), involvement (localized/generalized), histopathological features, concomitant diseases, differential diagnoses in cases with histopathology, regression time and recommended treatments were recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being under 18 years old
- •Having granuloma annulare
- •Applying to the Istanbul Training and Research Hospital, Dermatology Outpatient Clinic between 2008-2021
- •Consenting to participate in the study
排除标准
- •Being over 18 years old
结局指标
主要结局
Evaluation of the ages of the pediatric patients with granuloma annulare
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age (year)
Histopathological evaluation of the infiltration type of the pediatric patients with granuloma annulare
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neutrophilic, lymphocytic, lymphohistiocytic, eosinophil, mixed infiltrations
Histopathological evaluation of the infiltration pattern of the pediatric patients with granuloma annulare
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Interstitial, palisadic
Evaluation of epidermal findings
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regular/irregular, hyperkeratosis, acanthosis
Evaluation of the lesion type of the pediatric patients with granuloma annulare
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papule, pustule, plaque, nodule
Evaluation of the genders of the pediatric patients with granuloma annulare
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male, female
Evaluation of the lesion duration of the pediatric patients with granuloma annulare
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the time interval in between appearance of the lesion and diagnosis (month)
Evaluation of the clinical involvement
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localized, generalized
Evaluation of the concomitant diseases of the pediatric patients with granuloma annulare
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the concomitant diseases of the participants
Evaluation of the lesion localization of the pediatric patients with granuloma annulare
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head and neck, upper extremity, lower extremity, trunk
Evaluation of the mean size of the lesion
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diameter (cm)
Evaluation of depth of infiltrate
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superficial, medium, deep
次要结局
未报告次要终点
研究者
Ayse Esra Koku Aksu
Assoc. Prof.
Istanbul Training and Research Hospital