FAAH Availability in Psychiatric Disorders: A PET Study
试验速览
- 阶段
- 早期 1 期
- 状态
- 终止
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Total distribution of [11C]MK-3168 in the brain
研究概览
简要总结
The aim of the present study is to examine Fatty Acid Amide Hydrolase (FAAH) availability in humans, including healthy individuals and across a spectrum of psychiatric disorders in which alterations in the endocannabinoid system are observed.
详细描述
This study involves in vivo examination of FAAH availability, implicated both in the pathophysiology and therapeutics of disorders including PTSD, substance use disorders (e.g., alcohol use disorder, cannabis/cannabinoid use disorder, nicotine use disorder), psychotic disorders including schizophrenia, and mood disorders. The endocannabinoid system is a neuromodulatory system that has been implicated across a wide range of psychiatric disorders and may be implicated in the regulation of mood, appetitive behaviors, sleep, and cognition. Thus, alterations in the ECS have wide ranging implications. Finally, the ECS is being explored as a novel therapeutic target for several psychiatric disorders. Additionally, the test/retest reliability of the radiotracer, [11C]MK-3168, will be studied in up to 10 healthy control individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Between the ages of 18 and 65 years, inclusive
- •Good physical health as determined by history, physical and laboratory examinations, ECG, and vital signs
- •PTSD Inclusion Criteria:
- •Diagnosis of Post-Traumatic Stress Disorder
- •AUD Inclusion Criteria:
- •Diagnosis of Alcohol Use Disorder
- •Psychosis Inclusion Criteria:
- •Diagnosis of psychotic disorder such as Schizophrenia, Schizoaffective disorder
排除标准
- •Presence of ferromagnetic metal in the body or heart pacemaker
- •Women with a positive pregnancy test or women who are lactating
研究组 & 干预措施
[11C]MK-3168 PET Scan
干预措施: [11C]MK-3168 (Drug)
结局指标
主要结局
Total distribution of [11C]MK-3168 in the brain
时间窗: PET scan day
FAAH availability will be approximated using the FAAH positron emission tomography (PET) tracer \[11C\]MK-3168 total distribution
次要结局
未报告次要终点
研究者
Mohini Ranganathan
Associate Professor of Psychiatry
Yale University