Efficacy of seven and fourteen days of antibiotic treatment in uncomplicated Staphylococcus aureus bacterermia:A randomized, non-blinded, non-inferiority interventional study

Thomas Benfield0 个研究点目标入组 284 人开始时间: 2017年9月8日最近更新: 2023年12月12日

适应症

试验速览

暂无简介。

•Age > 18 years
•Blood culture positive for staphylococcus aureus
•Antibiotic treatment whit activity for S. aureus administrated within 12 hours of the first positive blood culture
•Temperature < 37,8 ?C (100 F) at randomization
•S. aureus negative follow-up blood culture obtained 48-120 hours after microbiological verified SAB.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 94
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 190

•Persistence S. aureus bacteremia before randomization ( Staph aureus positive control blood culture obtained 48-120 hours of the first positive blood culture)
•Polymicrobial infection
•Antibiotic treatment with no antibacterial activity for S. aureus administrated more than 12 hours of the first positive blood culture
•Endocarditis or other intracardiac infection demonstrated with transthoracic or transesophageal echocardiography
•Previous history of endocarditis or pacemaker/AICD infection
•Failure to remove a likely focus of infection, such as central venous catheter within 72 hours of the first positive blood culture.
•Infection involving bone, joins or foreign bodies.
•Pneumonia requiring oxygen supply at randomization.
•S. aureus infection within the last 90 days
•Pregnancy or breastfeeding
•Neutropenia (blood neutrophils < 1,0 x 109/l)
•Untreated terminal cancer
•Chemotherapy within 30 days
•Corticosteroid treatment (> 20mg/day prednisone or the equivalent for >14 days) within the last 30 days.
•Ongoing treatment with immunosuppresive agents (ATC code L04A)

发起方

Thomas Benfield