Acute Effects of Caffeine Supplementation on Resistance Training Volume and Blood Antioxidant Status in Resitance Trained Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Changes in markers of liver function
研究概览
简要总结
The purpose of this study is to verify the effect of acute caffeine intake on resistance training volume and blood antioxidant status, in a randomised, double-blind, placebo-controlled crossover trial.
详细描述
Caffeine is one of the most commonly consumed psychoactive substances in the world. Several previous studies confirmed that caffeine improves several aspects of exercise performance, including resistance training outcomes. Interestingly, caffeine and its catabolic products, theobromine and xanthine, exhibit antioxidant and prooxidant properties. Additionally, resistance training promotes the generation of reactive oxygen species, which are important for the cellular adaptation process.
Hovewer, to the best of our knowledge, there is no information as to how caffeine combined with resistance training affects blood antioxidant status. Therefore, the aim of this study was to examine acute effects of caffeine supplementation on resistance training volume and blood antioxidant status in resistance trained men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •written consent to participate,
- •medical permission by physician
- •"resistance-trained," defined as having a minimum of two years of resistance training experience
- •minimum of 2 workout sessions per week in the last 6 months
排除标准
- •neuromuscular or musculoskeletal disorders
- •current injury
- •using any medications, dietary supplements or ergogenic aids which could potentially affect the study outcomes
- •a positive smoking status
- •potential allergy to caffeine
结局指标
主要结局
Changes in markers of liver function
时间窗: Day 1, Day 2
Serum will be obtained for activity of ASPAT (aspartate aminotransferase), ALAT (alanine aminotransferase) and gamma glutamyltransferase (GGT)
Change the levels of oxidative stress markers
时间窗: Day 1, Day 2
Serum will be obtained for TOS/TOC (total oxidative stress), MDA (malondialdehyde), oncentration of TAS (total antioxidant status), activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx); concentartion of GSH (reduced glutathione) and UA (uric acid)
Changes in markers of muscle damage
时间窗: Day 1, Day 2
Serum will be obtained for activity of creatine kinase (CK) and lactate dehydrogenase (LDH), concentration of myoglobin (Mb)
Changes in Inflammation markers
时间窗: Day 1, Day 2
Serum will be obtained for level of interleukin 6, TNF alfa (tumor matrix factor), CRP (C-reactive protein)
次要结局
- Changes in muscle soreness(prior to exercise, and 24, 48, 72, 96 and 120 hours post exercise.)
- Changes in rate of perceived exertion after resistance training(Immediately after exercise protocol during caffeine and placebo treatment)
- Changes in heart rate during resistance training(During caffeine and placebo treatment)
- Changes in resistance training volume(During caffeine and placebo treatment)
研究者
Aleksandra Filip-Stachnik
PhD
The Jerzy Kukuczka Academy of Physical Education in Katowice